Diels-Alder, binding pocket, reaction rates.
2: 19-25.7.10.
Synthetic gene code provides binding pocket for diel-alder enzymatic reaction rate optimisation. From "Computational Designs of an Enzyme Catalyst for a Stereoselective Biomolecular Diels-Alder Reaction.
DOI:10.1126/science.1190239, from Science.
||Chemistry
Cortex, Human.
Differential regional pattern (some unexpected) of cortex surface suculi development observed as humans become adults. From Similar Patterns of Cortical Expansion during Human Development and Evolution.
DOI: 10.1073/pnas.1001229107, from PNAS.
||Biophysics.
Qualified approval for synthetic biology. Reported from http://www.bbsrc.ac.uk/web/FILES/Reviews/1006-synthetic-biology-dialogue-methodology.pdf, accessed prepublication.
ALS, Ataxin-2,TDP-43, RNA.
3:
23 - 29.8.10.
Ataxin-2 protein interaction with TDP-43 hints at an RNA related role as part of complex pathogenesis in ALS. From Ataxin-2 intermediate-lenghth polyglutamine expansions are associated with increased risk for ALS.
DOI:10:1038/nature09320, from Nature.
||Biology.
HapMap 3, population genetics, SNP, CNP.
4: 1 - 6.9.10.
Initial analysis of expanded HapMap (HapMap 3) database with attention to the quality of imputation across populations. From Integrating common and rare genetic variations in diverse human populations by The International HapMap 3 Consortium.
DOI:10.1038/nature09298, from a paper in Nature.
||Statistics in biology.
Quantum communication,
quantum repeaters, megahertz transmission.
A bilateral linear design for quantum communication by entanglement swapping that demonstrates the potential feasibility for quantum communication networks with megahertz transmission rates. From ...quantum multiplexing to high-performance quantum networking.
DOI:10.1038/NPHOTON.2010.213, from Nature Photonics.
||Physics.
PIK3CA, ARID1A,PPP2R1A, KRAS.
5: 6 - 12.9.10.
Exomic analysis of the genetics of ovarian clear cell carcinoma. From Frequent mutations of chromatin remodeling gene ARID1A in ovarian clear cell carcinoma.
DOI:10.1126/science.1196333, from Science.
||From science to medicine.
Amyloid beta,
glucose metabolism, brain cellular dynamics.
6: 14 - 19.9.10.
Amyloid burden distribution in dementia of Alzheimer's type (DAT) suggests the need for a deeper understanding of glucose metabolic end-to-end pathway and final product outcome, location and fate. From Spatial correlation between brain aerobic glycolysis and amyloid (beta) (A beta) deposition.
DOI:10.1073/pnas.1010461107, from PNAS.
||Biochemistry.
Normal brain,aerobic glycolysis.
Brain regions involved in cognitive control, working memory and some parts of the default mode network exhibit elevated aerobic glycolysis. From Regional aerobic glycolysis in the human brain.
DOI:10.1073/pnas.1010459107, from PNAS.
||Biochemistry.
rhodopsin, photophysics, potential energy transitions.
7: 21 - 27.9.10.
Demonstration of conical pathway for potential energy transition from cis to trans rhodopsin with sub 20 femto second optical microscopy from optical to near infrared. From Conical intersection dynamics of the primary photoisomerization event in vision.
DOI:10.1038/nature09346, from Nature.
||Biophysics.
HIV, gp140, heterogenous, bivalent immunoglobulin binding.
8: 28.9 - 4.10.10.
Polyreactivity, disfavoured when B-cells develop from haematoipoetic stem cells (HSC), is observed in three quarters of the 134 unique antibodies to gp140 isolated from 6 HIV infected patients. From Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation.
DOI:10.1038/nature09385, from Nature.
||Immunology.
Nanostructures, single silicon crystal, heteroepitaxy.
9: 5.10 - 11.10.10.
Order of magnitude improvement in feature size within homo and heteroepitaxic silicon-silicon and silicon-NiSi single crystal nanostrucures, to achieve features of 30 to 35 nanometre distance. From Block copolymer, self assembly-directed single-crystal homo and heteroepitaxial nanostructures.
DOI: 10:1126/science.1193369, from Science.
||Chemistry.
P.falciparum, preerythrocyte antigens, vaccine efficacy statistical model.
10: 13.10 - 19.10.10.
Mathematical model that predicts efficacy of 0.75 for a vaccine working in combination against two hepatic merozoite antigens also gives tool for discussing biology of other P. falciparum's antigens during the parasite's life cycle using antibody titre field data from 2001 and observations from the literature. From "Efficacy for antibody-mediated preerythrocyte malaria vaccines". DOI:10.1098/rspb.2010.1697, from The Proceedings of the Royal SocietyB.
||Immunology.
piRNA, deadenylation and translation silencing, embryogenesis of Drosophilia Melanogaster.
11: 20.10 - 27.10.10.
Biochemical actors in the deadenylation and decay of specific mRNAs during embryogenesis of Drosophilia Melanogaster. From Maternal mRNA deanylation and decay by the piRNA pathway in the early Drosophilia embryo.
DOI:10:1038/nature09465, from Nature.
||Biology.
hESCs differentiation, hESC self renewal, induced pluripotency.
Characterisation via a GFP-marked hES cell line as primary screen of aspects (my emphasis - HG) of: hESC self renewal; natural differentiation to plutipotency; and reversal of pluripotency to undifferentiated hESCs for reprogramming. From A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity.
DOI:10.1038/nature09531, from Nature.
||Biology.
Competing visual stimuli, neuronal response, medial temporal lobe, brain.
12: 27.10 - 2.11.10.
Medial temporal lobe shown to have physical capacity for neuronal direction of response to competing external stimuli working via internal electronic representation of the competing external visual stimuli. From On-line, voluntary control of human temporal lobe neurons.
DOI:10.1038/nature09510, from Nature.
||Neurology.
H2,H3,H4 histone acetylations and methylations, gene architecture, STIM1 gene.
13: 3.11 - 9.11.10.
Not written. See issue and an associated illustration by Helen Gavaghan. This story was to have been based on Reciprocal intronic and exonic histone modification regions in humans.
DOI: 10.1038/nsmb.1924, from Nature Structural and Molecular Biology.
||Biology.
